A method of producing a packaging structure, including a step of coating at least one surface of a first sheet base material and/or a second sheet base material with a latex of a synthetic polyisoprene having a weight average molecular weight of 500,000 to 5,000,000 and/or a styrene-isoprene-styrene block copolymer having a weight average molecular weight of 100,000 to 300,000, a step of sandwiching an article to be packaged in a state in which the first sheet base material and the second sheet base material are in contact with each other via a latex coated surface formed on the first sheet base material and/or the second sheet base material to thereby obtain a laminated body, a step of pressing a portion where at least the first sheet base material and the second sheet base material of the laminated body are in contact with each other via the latex coated surface at a temperature of 100°C or less to thereby obtain a pressed laminated body, and a step of performing a sterilization treatment on the pressed laminated body.