DERIVES DE BREVETOXINE DE POLYETHER UTILISES EN TANT QU'AGENTS THERAPEUTIQUES POUR TRAITER LA MUCOVISCIDOSE, UN DYSFONCTIONNEMENT MUCOCILIAIRE ET DES MALADIES PULMONAIRES

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专利权人:

UNIVERSITY OF NORTH CAROLINA AT WILMINGTON

发明人:

BADEN, DANIEL G.,ABRAHAM, WILLIAM M.,BOURDELAIS, ANDREA J.

申请号：

CA2539590

公开号：

CA2539590C

申请日:

2004.09.20

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Disclosed are compounds that are derivatives of brevetoxin, or PbTx,pharmaceutical formulations comprising the compounds, and methods ofregulating mucus transport in a cell, treating mucociliary dysfunction anddiseases related to decreased mucus transport, wherein the compounds are ofthe Formula (I), and Formula (III): Formula (I), Formula (III) wherein R, R1,R2, R3, A, n, and Y are as defined herein for each compound.

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