LESTERHUIS, WILLEM JOOST,LAKE, RICHARD,BOSCO, ANTHONY,ZEMEK, RACHAEL,DE JONG, EMMA
申请号：
CA3094500
公开号：
CA3094500A1
申请日:
2019.03.22
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides a method that at least promotes, drives or directs a non-responsive neoplastic microenvironment towards a responsive phenotype. More particularly, the invention provides a method for enhancing the sensitivity of one or more neoplastic tumour to check point blockade agents. The present invention also provides a method for predicting the likelihood of responses to immune checkpoint blockade agents, bz measuring STATI activation and/or increase in NK cell number within the tumour microenvironement.
