A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. A separation process of non-toxic radio- high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with alumina solid-phase column in advance to obtain the crude product with fluorine-18 removed. Then, diphenyl semi-preparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction rate about 50 percent (%). The method has an uncorrected radiochemical yield of 10~20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.一種[F-18]FEONM之高壓純化方法，係整合[F-18]FEONM之合成過程，並使用一種無毒之放射性高效率液相色層分析（radio- High performance liquid chromatography, radio-HPLC）分離製程純化其粗產物。整個過程將一個傳統之[F-18]FDG合成器與一個新的放射性HPLC系統結合在一個熱室中。在放射氟化前驅物後，反應產物係預先經氧化鋁固相萃取管柱純化得到粗產物以除去氟-18氟化物，再使用二苯基半製備型HPLC柱進行最終純化，通過使用無毒溶劑作為流動相洗脫以除去未反應之前驅物與相轉移溶劑。放射氟化反應率約為50%。整個過程之未校正放射化學產率為10～20%。放射性HPLC與放射性薄層色層分析（radio-Thin layer chromatography, radio-TLC）之放射化學純度都高於95%。
