Cornell University;Southern Research Institute;The UAB Research Foundation
发明人:
Parker, William B.,Sorscher, Eric J.,Ealick, Steven E.
申请号：
AU2016231630
公开号：
AU2016231630A1
申请日:
2016.09.23
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016231630A120161020.pdf#####ABSTRACT [0102] A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-( -D-arabinofuranosyl)-2-fluoroadenine (F-araA).
