(8s, 9r) -5-fluor-8- (4-fluorophenyl) -9- (1-methyl-1h-1,2,4-triazol-5-yl) -8,9-dihydro-2h tosylate salt -pyrido [4,3,2-de] phthalazin-3 (7h) -one, method for preparing a crystalline form and use thereof, pharmaceutical composition and method for treating cancer or a symptom thereof.

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专利权人:

BIOMARIN PHARMACEUTICAL INC

发明人:

BING WANG,DANIEL CHU,SCHICHUN PENG,YONGBO LIU

申请号：

BR112013009117

公开号：

BR112013009117A2

申请日:

2011.10.20

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

(8s, 9r) -5-fluor-8- (4-fluorophenyl) -9- (1-methyl-1h-1,2,4-triazol-5-yl) -8,9-dihydro-2h tosylate salt -pyrido [4,3,2-de] phthalazin-3 (7h) one, method for preparing a crystalline form and use thereof, pharmaceutical composition and method for treating a symptom thereof. forms of (8s, 9r) -5-fluor-8- (4-flurfenyl) -9- (1-methyl-1h-1,2,4-triazol-5-yl) -8 tosylate salt are provided herein, 9-Dihydro-2h-pyrido [4,3,2-de] phthalazin-3 (7h) -one, including crystalline forms, and methods of their preparation. Pharmaceutical compositions also comprising (8s, 9r) -5-fluor-8- (4-fluorophenyl) -9- (1-methyl-1h-1,2,4-triazol-5-yl) -8 tosylate salt are provided. 9-dihydro-2h-pyrido [4,3,2-de] phthalazin-3 (7h) -one as well as the methods of using (8s3,9r) -5-fluor-8- (4) tosylate salt -flurophenyl) -9- (1-methyl-1h-1,2,4-triazol-5-yl) -8,9-dihydro-2h-pyrido [4,3,2-de] phthalazin-3 (7h) -one to treat a disease or condition, such as a cancer.sal tosilato de (8s,9r)-5-fluor-8-(4-fluorfenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-diidro-2h-pirido[4,3,2-de]ftalazin-3(7h)ona, método para preparar uma forma cristalina e uso do mesmo, composição farmacêutica e método para tratar um sintoma do mesmo. são aqui proporcionadas formas do sal tosilato de (8s,9r)-5-fluor-8-(4-flurfenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-diidro-2h-pirido[4,3,2-de] ftalazin-3 (7h)-ona, incluindo formas cristalinas, e métodos de sua preparação. também são providas composições farmacêuticascompreendendo um sal tosilato de (8s,9r)-5-fluor-8-(4-fluorfenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-diidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona, assim como os métodos de uso do sal tosilato de (8s3,9r)-5-fluor-8-(4-flurofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-diidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona para tratar uma doença ou condição, tal como um câncer.

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