The present disclosure relates to a system for physiological signal quality assessment, the system includes: a first filter module for implementing a filter process on an inputted first physiological signal; a first periodicity detection module for detecting periodicity of the filtered first physiological signal, and determining periodic segmentation point of the first physiological signal; a feature extracting module for extracting corresponding signal features of the first physiological signal in each heart period; and a fuzzy logic module for building up a fuzzy logic model according to the extracted signal features, and calculating a signal quality index for the first physiological signal in the relative period based on the built fuzzy logic model, and determining a signal attribute according to the signal quality index. A method for physiological signal quality assessment is provided as well. The system and method for physiological signal quality assessment calculate the signal quality index, determine the signal attribute according to the signal quality index, therefore recognize the abnormal signal out of the first physiological signal, and result in high quality physiological signals.