This disclosure relates to a novel class of compounds having the structure of formula I as defined herein and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. This disclosure also comprises methods of treating a subject by administering a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof to the subject. These compounds are useful for the conditions disclosed herein. This disclosure further comprises methods for making the compounds of formula I and corresponding intermediates.Cette invention concerne une nouvelle classe de composés répondant à la structure de la formule I et des compositions pharmaceutiques comprenant un composé de formule I ou un sel pharmaceutiquement acceptable de celui-ci. Ces composés inhibent ou réduisent la ferroptose et/ou l'oxytose, deux formes de mort cellulaire non apoptotiques, ce qui les rend utiles pour le traitement des diverses affections mentionnées dans la description.
