The present invention provides a combination of pharmaceutical preparations for tumor chemotherapy, comprising a cell vesicles preparation with cell vesicles derived from apoptotic tumor cells for sensitizing tumor cells, and a chemotherapy drugs preparation for treating tumors. The combination of pharmaceutical preparations for tumor chemotherapy provided by the present invention uses cell vesicles derived from apoptotic tumor cells as sensitizers of tumor cells, in combination with the chemotherapy drugs preparation for treating tumors, may allow more chemotherapy drugs to enter tumor cells, so as to achieve reversal of drug resistance characteristic of tumor cells, and enhance killing effects of chemotherapy drugs against tumor cells.
