CHEN, John,FRANSSON, Johan,FURSOV, Natalie,HAMEL, Damon,MALIA, Thomas,OBMOLOVA, Galina,ORT, Tatiana,RYCYZYN, Michael,SCULLY, Michael,SWEET, Raymond,TEPLYAKOV, Alexey,WHEELER, John,ALMAGRO, Juan Carlos
申请号：
PH12017501908
公开号：
PH12017501908A1
申请日:
2017.10.19
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
