The invention relates to virology and the prevention and/or treatment of viralinfection and disease in animals, includingbirds and humans. The invention relates to the field of antiviral treatments.The invention further relates to methods ofstimulating innate immunity and natural interferon production in humans oranimals and in component parts of humans or animals,including cells and tissues. The invention also relates to the field ofdefective interfering (D1) viruses, including cloned D1viruses.