SWIDORSKI, Jacob,MEANWELL, Nicholas A.,REGUEIRO-REN, Alicia,SIT, Sing-Yuen,CHEN, Jie,CHEN, Yan
申请号：
ES13707493
公开号：
ES2656984T3
申请日:
2013.02.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound selected from the group consisting of: a compound of formula I ** Formula ** a compound of formula II ** Formula ** a compound of formula III ** Formula ** and a compound of formula IV ** Formula * * in which R1 is isopropenyl or isopropyl； J and E are independently -H or -CH3, and E is absent when the double bond is present； X is selected from the group C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxocycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxocycloalkenyl, C6- cycloalkenyl, C6- cycloalkenyl, C6-6 alkenyl C6 oxaccyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl, in which X is substituted with A, in which A is at least one member selected from the group of -H, -halo, -hydroxyl, -C1-6 alkyl , -C 1-6 alkoxy, -C 1-6 alkyl, -C 1-6 alkyl substituted with alkyl-Q, -CN, -CF2Q, -NR8R9, -COOR2 and -CONR2R2. X can also be selected from the group of: ** Formula ** in which Q is selected from the group of aryl, heteroaryl, substituted heteroaryl, -OR2, -COOR3, -NR2R2, - SO2R7, -CONHSO2R3, and -CONHSO2NR2R2 ； R 2 is -H, -C 1-6 alkyl, -C 1-6 alkyl substituted with C 1-6 alkyl or aryl substituted with alkyl； Y is selected from the group of -COOR2, -C (O) NR2SO2R3, -C (O) NHSO2NR2R2, -NR2SO2R2, -SO2NR2R2, - C3-6 -C10 -alkyl alkyl, -C2 -alkenyl 6-COOR2, -C1-6 alkyl-COOR2, -C1-6 alkyl substituted with alkyl, CF2-COOR2, -NHC (O) (CH2) n-COOR2, -SO2NR2C (O) R2, -tetrazol, and -CONHOH , in which n>； = 1-6； W is absent, CH2 or CO； R3 is -C 1-6 alkyl or -C 1-6 alkyl substituted by alkyl； R4 is selected from the group of -H, -C1-6 alkyl, -C1-6-C alkyl (OR3) 2-C3-6 cycloalkyl, -C1-6 substituted alkyl, - C1-6 alkyl-C3-6 cycloalkyl , -C1-6-Q1 alkyl, -C1-6 alkyl-C3-6-Q1 cycloalkyl, aryl, heteroaryl, substituted heteroaryl, -COR6, -COCOR6, -SO2R7, -SO2NR2R2, ** Formula ** with the condition of that R4 or R5 cannot be COR6 or COCOR6 when W is CO； wherein Q1 is selected from the group of heteroaryl, substituted heteroaryl, h
