Inis Biotech LLC;Fundación Sales;Consejo Nacional de Investigaciones Cientificas y Técnicas
发明人:
Rabinovich, Gabriel Adrián,Di Lella, Santiago,Estrin, Dario Ariel,Carmelo, Julio Javier
申请号：
AU2016252737
公开号：
AU2016252737A1
申请日:
2016.04.21
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the mutation being a substitution of the histidine to tyrosine or asparagine, providing resistance to acidosis otherwise resulting in deactivation of the native human Gal-1. The Galectin-1 polypeptide variants may include one or more additional mutation(s) of the cysteine residue corresponding to a position selected from 2, 16, 88, or combinations thereof of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the additional mutation being a substitution of the cysteine to serine, and providing resistance to oxidation.
