Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.本文中提供生物醫學裝置以及製作及使用用於感測及致動應用之生物醫學裝置之方法。舉例而言，提供撓性及/或可拉伸生物醫學裝置，其包括適用於建立與一生物環境中之一組織之原位適形接觸之電子裝置。本發明包括可植入電子裝置及施用至一目標組織之表面之裝置，舉例而言，以用於自一組織(例如，心臟、腦組織或皮膚)獲得電生理學資料。
