The present invention is directed to therapeutic methods and compositions for treating non-small cell lung cancer in a subject comprising administering an effective amount of an extract or powder of a herbal mixture, optionally with an anti-cancer agent to said subject. The herbal mixture comprises a component of at least one species from each of the genus Astragalus, Cimicifuga Foetida Rhizoma, Ophiopogon Radix, Atractylodes Lancea Rhizoma, Panax Ginseng- Red, Atractylodes Rhizoma-White, Massa Medicata Fermentata, Citrus Reticulata-Viride, Citrus Reticulata, Glycyrrhiza Radix, Schisandra Fructus, Angelica Sinensis Radix, Phellodendron Cortex, Alisma Rhizoma, Pueraria Radix, Ziziphus Fructus-Red, and Zingiber Officinale Radix.