Drug delivery system comprising a main portion with a cap as well as a needle assembly with a needle mounted in a hub and a needle cap releasably mountable on the hub to cover the needle. The cap comprises gripping means reversibly operatable between a first condition in which there is no gripping engagement between the mounted cap portion and the needle cap this allowing the cap portion to be removed from the main portion without removing the needle cap from the hub and a second condition in which the cap portion grippingly can en-gage the needle cap of a needle assembly this allowing the needle cap to be removed from the hub together with the cap. The cap further comprises user actuation means for operating the gripping means between the two conditions.
