There is provided a method of treating an inflammatory response to infection and complications associated therewith, by administering a proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor to a subject, in need thereof. There is also provided a method of treating or preventing treating or preventing renal failure renal dysfunction respiratory failure respiratory dysfunction or acute lung injury. Provided herein are uses, pharmaceutical compositions, and commercial packages associated therewith.
