DEVASTHALE, PRATIK,MOORE, FANG,ZHAO, GUOHUA,PIENIAZEK, SUSAN NICOLE,SELVAKUMAR, KUMARAVEL,DHANUSU, SURESH,PANDA, MANORANJAN,MARCIN, LAWRENCE R.
申请号：
CA3042710
公开号：
CA3042710A1
申请日:
2017.11.07
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to av- containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of av-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
