PROBLEM TO BE SOLVED: To provide a chimeric non-human animal having a human hepatocyte population in the body thereof, wherein the influence of the metabolism of a drug by cells of the non-human animal is suppressed or deleted.SOLUTION: The method for producing the chimeric non-human animal in which a drug metabolism system is deleted or suppressed and which has a drug metabolism system to be driven by a human hepatocyte comprises transplanting a human hepatocyte into a non-human animal that is characterized in that (i) the non-human animal is immunocompromised, (ii) the non-human animal is suffered from a hepatic disorder and (iii) the function of endogenous Cyp3a gene is deleted in the non-human animal.COPYRIGHT: (C)2013,JPO&INPIT【課題】非ヒト動物の細胞による薬物代謝の影響を抑制または欠失させた、ヒトの肝細胞集団を体内に有するキメラ非ヒト動物を提供する。【解決手段】(i)免疫不全であること、(ii)肝障害を受けていること、および(iii)内在性のCyp3a遺伝子の機能が欠失していること、を特徴とする非ヒト動物に、ヒト肝細胞を移植することを含む、該非ヒト動物の薬物代謝系が欠失または抑制され、かつ該ヒト肝細胞による薬物代謝系を備えるキメラ非ヒト動物の作出方法。【選択図】なし
