FIELD: medicine.SUBSTANCE: group of inventions relates to medical equipment. High frequency positive pressure ventilation system comprises an inspiratory subsystem for generating a flow of respiratory gas under pressure to be supplied to the patient's airways. Expiratory channel connects to an expiratory flow generator through an exhalation valve. Expiratory flow generator is configured to remove gas from the patient's airways to the system outlet. Sensors are configured to generate output signals transmitting information associated with gas parameters in or near the patient's airways. Exhalation valve is configured to control flow from the patient's airways through the expiratory flow generator. Processors are configured to receive information related to the output signals of the sensors and are configured to execute computer program modules. Parameter module is configured to determine gas parameters in or near the patient's airways based on the output signals and to determine the time-averaged pressure level in the airways using gas pressure parameters. Target module is configured to obtain target values for the gas parameters and to obtain the target time-averaged pressure level in the airways. Control module is configured to control the inspiratory subsystem, the expiratory flow generator, and the exhalation valve, using sensor output signals and time-averaged pressure values in airways in order to maintain a time-average pressure level in airways equal to the target time-averaged pressure level in airways during a sequence of high-frequency pressure cycles. Method for operating the system is disclosed.EFFECT: inventions provide for the adjustment of high-frequency ventilation parameters depending on the change in the patient's lung condition.10 cl, 3 dwgГруппа изобретений относится к медицинской технике. Система высокочастотной вентиляции с положительным давлением содержит инспирационную подсистему формирования потока дыхательного газа под давлением для подачи