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ANHYDROUS AND HYDRATE FORMS OF CRYSTALLINE 2- ( (2S, 3R, 4E, 6E, 1OE, 12S) -13- (4-FLUOROPHENOXY)-2,3,12- (TRIHYDROXYTRIDECA-4, 6, 10-TRIEN-8-YNYL)OXY) ACETIC ACID
专利权人:
发明人:
KLAUS BARTEL,DANJA GROSSBACH,WILLIAM GUILFORD,MICHAEL SANDER,GABRIELE WINTER
申请号:
IN8522/DELNP/2010
公开号:
IN2010DN08522A
申请日:
2010.12.01
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
R1 is -0-, -S(0)t- (where t is 0, 1 or 2), or a straight or branched alkylene chain and R2 is aryl (optionally substituted by one or more substituents selected from alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (optionally substituted by one or more substituents selected from f alkyl, alkoxy, halo, haloalkyl and haloalkoxy) and wherein the compound of Formula (II) is a single stereoisomer or any mixture of stereoisomers. This crystalline acid is useful in treating disease-states characterized by inflammation, such as inflammatory and autoimmune disorders or pulmonary or respiratory tract inflammations in humans. Methods of preparing the crystalline acid are also described.
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