Buffers for stabilization of lentiviral preparations

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专利权人:

Novartis AG;The Trustees of the University of Pennsylvania

发明人:

Amitabha Deb,Eugene Nebelitsky,Vladimir Slepushkin

申请号：

US15777290

公开号：

US10724006B2

申请日:

2016.11.18

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The invention provides lentiviral preparations containing a sulfonic acid buffer, such as 1,4-piperazinediethanesulfonic acid (PIPES), 2-(N-morpholino)ethanesulfonic acid (MES), and 3-morpholinopropane-1-sulfonic acid (MOPS), a sodium citrate buffer, or a phosphate buffer. The invention additionally encompasses methods of lentiviral purification as well as methods of transducing human cells.

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