FANG TIANAN,PINTO DONALD J.P.,YANG WU,CORTE JAMES R.,DE LUCCA INDAWATI,DILGER ANDREW K.,PABBISETTY KUMAR BALASHANMUGA,EWING WILLIAM R.,ZHU YEHENG,WEXLER RUTH R.,ORWAT MICHAEL J.,SMITH II LEON M.,WANG
申请号：
CL2017000712
公开号：
CL2017000712A1
申请日:
2017.03.24
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
<； p >； This Invention Bertalanffy provides compounds of formula (i) or estereois & amp； Taut & acute； groupers, groupers or Pharmaceutical acceptable salts uticamente & eacute； of the same, wherein all variables are as defined herein. These compounds are Selective inhibitors of factor XIa inhibitors or dual fxia and kallikrein plasm & aacute； tica.Also & eacute； refers to pharmaceutical compositions & eacute； Treatment comprising these compounds and to M & eacute； All to treat Disorders tromboemb & amp； Liquor and / or inflammatory through use. <； / p >；LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE MACROCICLOS, INHIBIDORES DEL FACTOR XIA, A UNA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE Y A SU USO EN EL TRATAMIENTO Y/O PROFILAXIS DE UNA ENFERMEDAD TROMBOEMBOLICA.
