The present relates to immunogenic compositions comprising a Protein cdta and cdtb isolated a Protein of Clostridium difficile.In particular, The Protein cdtb Clostridium difficile isolated is, ideally, a truncated Protein cdtb which includes the domain of receptor binding or Protein cdtb Murada that cannot bind to TSP and TSP Protein of Clostridium difficile isolated is ideally a protein C DTA does not include the truncated c-terminal domain.In particular, This also relates to fusion proteins comprising a Protein and a Protein cdta and cdtb, also, fusion proteins between a protein isolated from Clostridium difficile Toxin a and / or B isolated from Clostridium difficile Toxin Protein FUSED to a Protein cdtb.This also relates to compositions comprising Fragments or variants of sec sec id id no. 3, no. 7, no. 16 sec SEC ID, ID no. 9 SEC ID no. 51, no. 34 SEC SEC ID, ID no. 36, no. 50 sec SEC ID, ID no. 14, ID no. 15 sec, sec id no. 46, No. 48 sec SEC ID, ID no. 52 SEC ID no. 54 sec ID no. 40, no. 41 sec SEC ID or ID no. 42 or 43 sec id no. or SEC sec id id no. 44 or 45.Claim 1: an immunogenic composition comprising the Protein cdtb of Clostridium difficile in the composition further comprises an isolated Protein that has a similarity of at least 70%, 75%, 80%, 85%, 90%, 95%, 98%, 99% and 100% with the SEC ID no. 1 The SEC ID n No. 31 or 32 SEC ID no..La presente se refiere a composiciones inmunogénicas que comprenden una proteína CDTa y una proteína CDTb de Clostridium difficile aislada. En particular, la proteína CDTb de Clostridium difficile aislada es, idóneamente, una proteína CDTb truncada que comprende el dominio de unión al receptor o una proteína CDTb murada que no se puede unir a CDTa y la proteína CDTa de Clostridium difficile aislada es idóneamente una proteína CDTa truncada que no comprende el domino en C-terminal. En particular, la presente también se refiere a proteínas de fusión que comprenden una proteína CDTa y una proteína CDTb y, también, proteína
