The present invention relates to a pharmaceutical formulation in colloidalform for topical application for the therapy and prophylaxis of pathologicalchanges of the skin and/or integumentary structures of the skin and/ormucous membranes, including mucous membranes of the digestive tract,uro-genital tract and bronchial system and/or conjunctiva, containing alipophilic phase in a quantity of 1 - 10% by weight, a mixture ofsurfactant and co-surfactant in a quantity of 1 - 50% by weight, ahydrophilic phase in a quantity of 40 - 80% by weight and, as activeingredient, cyclosporin and/or derivatives thereof in a concentration of 0.1- 20% by weight.
