This invention provides a method for treating upper respiratory tract infection in a subject, comprising administering to the subject an effective amount of a recombinant interferon, wherein the recombinant interferon has the amino acid sequence of SEQ ID NO:1 and is encoded by the nucleotide sequence SEQ ID NO:2. The upper respiratory tract infection can be induced by various viruses such as rhinovirus, coronavirus, respiratory syncytial virus, influenza, parainfluenza, adenoviruses, coxsackie virus, corona virus and enterovirus.