TO PROVIDE PHARMACEUTICAL PREPARATION EXHIBITING SATISFACTORY DISSOLUTION PROPERTY IN A WIDE PH RANGE. THE PHARMACEUTICAL COMPOSITION IS CHARACTERIZED BY CONTAINING (A) N1-(5-CHLOROPYRIDIN-2-YL)-N2-((1S,2R,4S)-4-[(DIMETHYLAMINO)CARBONYL]-2-{ [(5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDIN-2-YL)CARBONYL]AMINO}CYCLOHEXYL)ETHANEDIAMIDE, REPRESENTED BY THE FOLLOWING FORMULA (1), A PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF, OR A HYDRATE OF ANY OF THESE, AND (B) ONE OR MORE SPECIES SELECTED FROM THE GROUP CONSISTING OF A SUGAR ALCOHOL AND A WATER-SWELLING ADDITIVE.
