An IL-1beta binding molecule comprising both the light chain (VL) and heavy chain (VH) variable domains in which said IL-1beta binding molecule contains at least one antigen binding site comprising: <；br />； <；br />； a) an immunoglobulin (VH) heavy chain variable domain comprising the hypervariable regions in the CDR1, CDR2 and CDR3 sequence, said CDR1 having the Val-Tyr-Gly amino acid sequence - Met-Asn, said CDR2 having the amino acid sequence Ile-Ile-Trp-Tyr-Asp-Gly-Asp-Asn-Gln-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly, and said CDR3 having the amino acid sequence Asp-Leu-Arg-Thr-Gly-Pro； and <；br />； <；br />； b) an immunoglobulin (VL) light chain variable domain comprising the hypervariable regions in sequence CDR1 '', CDR2 '' and CDR3 '', said CDR1 '' having the sequence of amino acids Arg-Ala-Ser-Gln-Ser-Ile-Gly-Ser-Ser-Leu-His said CDR2 "having the amino acid sequence Ala-Ser-Gln-Ser-Phe-Ser and said CDR3" having the sequence of His-Gln-Ser-Ser-Ser-Leu-Pro amino acids； and the direct equivalents thereof in which the hypervariable regions CDR1, CDR2, CDR3, CDR1 '', CDR2 '' and CDR3 '' taken as a whole are at least 95% homologous to the hypervariable regions under a) and b), and have a binding specificity for the antigenic epitope of IL-1beta that includes the loop that includes the Glu 64 residue of human mature IL-1beta.Una molécula de enlazamiento a la IL-1beta que comprende tanto a los dominios variables de cadena liviana (VL) como de cadena pesada (VH) en los cuales dicha molécula de enlazamiento a la IL-1beta contiene al menos un sitio de enlazamiento del antígeno que comprende: <；br />；<；br />；a) un dominio variable de cadena pesada de inmunoglobulina (VH) que comprende a las regiones hipervariables en secuencia CDR1, CDR2 y CDR3, dicha CDR1 teniendo la secuencia de aminoácidos Val-Tyr-Gly- Met-Asn, dicha CDR2 teniendo la secuencia de aminoácidos Ile-Ile-Trp-Tyr-Asp-Gly-Asp-Asn-Gln-Tyr- Tyr-Ala-Asp-Ser-Val-Lys-Gly, y dicha CDR3 teniendo la
