Jankowski, Ronald,Chancellor, Michael B.,Pruchnic, Ryan,Payne, Thomas
申请号：
AU2007325698
公开号：
AU2007325698B2
申请日:
2007.11.28
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides muscle-derived progenitor cells that show long-termsurvival following transplantation into body tissues and which can augmentsoft tissue following introduction (e.g. via injection, transplantation,or implantation) into a site of soft tissue. Also provided are methods of isolatingmuscle-derived progenitor cells, and methods of genetically modifying thecells for gene transfer therapy. The invention further provides methods of usingcompositions comprising muscle-derived progenitor cells for the augmentationand bulking of mammalian, including human, soft tissues in the treatment of variouscosmetic or functional conditions, including malformation, injury, weakness,disease, or dysfunction. In particular, the present invention provides treatmentsand amelioration for dermatological conditions, gastroesophageal reflux,vesico-ureteral reflux, urinary incontinence, fecal incontinence, heartfailure, and myocardial infarction.
