The present invention discloses quinoline compounds, a preparation method thereof, and a use thereof as a urate transporter inhibitor drug. The compounds and salts, hydrates or solvates thereof provided in the present invention, as a selective uric acid reabsorption inhibitor, have the effect of reducing uric acid in animal and human body and can treat hyperuricemia and gout by promoting secretion of uric acid from the body and reducing serum uric acid.