This invention relates to novel compounds that are 4-oxoquinoline derivativesand pharmaceutically acceptable salts thereof. More specifically, this inventionrelates to novel 4-oxoquinoline derivatives that are derivatives of elvitegravir.This invention also provides pyrogen-free compositions comprising one or morecompounds of this invention and a carrier, and the use of the disclosed compoundsand compositions in methods of treating diseases and conditions that are beneficiallytreated by administering an HIV integrase inhibitor, such as elvitegravir.