JOHNS HOPKINS UNIVERSITY;FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.;The United States of America, as represented by the Secretary, Department of Health and Human Servic
The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof； methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo； pharmaceutical compositions； packaged dosage formulations； and kits for treating or preventing Flavivirus infections, such Zika virus infections.
