YANG, DAVID J.,杨敬文,楊敬文,WU, YEN SHIAN,吴彦显,吳彥顯,CHEN, HSIEN FAN,陈宪范,陳憲範,LO, YUN CHI,罗韵绮,羅韻綺,HSU, CHIH WEI,许智为,許智為,TSAO, NING,曹宁,曹寧
申请号：
TW101132948
公开号：
TW201340980A
申请日:
2012.09.10
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one liner covalently bound to the polysaccharide. The conjugate also has at least on 5 e metal conjugated by said linker. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a linker to a polysaccharide to obtain an intermediate and by conjugating said intermediate to a metal to form a polysaccharide conjugate. This conjugate has a higher relaxivity, so it is suitable to be used as a contrast medium for hybrid camera.本發明的一個實施態樣包括一多醣體共軛物。該共軛物具有一多醣體及至少一共價鍵結至前述多醣體的連結基團。該共軛物尚具至少一經前述連結基團共軛的金屬。根據本發明的另一實施態樣,本揭露內容提供一種合成一多醣體共軛物的方法,其係使一連結基團共價鍵結至一多醣體以取得一中間產物,再使前述中間產物共軛至一金屬以形成一多醣體共軛物。該共軛物具有較高的弛緩率,因此合適作為雜合攝影之顯影劑。
