A method of treating liver cirrhosis has ‘micro-cuts’ being created within the parenchyma of a cirrhotic liver to create ‘micro-cavities’, so that hepatocytes have more ‘room’ to regenerate； and thus an overall increase in hepatocyte volume occurs. Alternatively, the method of treating liver cirrhosis has fibrotic collagen being disrupted enzymatically (eg collagenase) through localized intra-parenchymal injections. The increase in hepatocyte volume at focal sites of mechanical fibrosis disruption (via ‘cuts’ or ‘collagenase’) provides for a ‘whole-organ’ treatment of a cirrhotic liver.
