PROBLEM TO BE SOLVED: To provide a composition for inhibiting PAR2 activation of keratinocytes.SOLUTION: The composition comprises: a vitamin B3 compound an N-acyl amino acid compound and a Laminaria Saccharina extract. In one embodiment, the composition for inhibiting PAR2 activation of keratinocytes comprises: niacinamide N-undecylenoyl-L-phenylalanine and a Laminaria Saccharina extract. In response to the technical problems identified in the background, the present invention may take other forms including methods for inhibiting PAR2 activation of keratinocytes.