Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling

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专利权人:

发明人:

Moshe Arditi,Pearl S. Gray

申请号：

US14639782

公开号：

US09512196B2

申请日:

2015.03.05

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention is based on a novel, alternatively spliced human isoform of MD-2 (MD-2s). In addition, the present invention relates to modified MD-2 proteins, wherein one or more tyrosine residues have been mutated to phenylalanine. In various embodiments, the invention relates to methods and kits for preventing, reducing the likelihood of developing and/or treating various conditions using MD-2s. The invention also describes methods of determining the risk of a subject to various conditions.

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