Solvate form M of trametinib dimethyl sulfoxide and methods of making and using thereof

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专利权人:

发明人:

Chenyang Hu,Xiaoxia Sheng,Xiaohong Sheng

申请号：

US14320284

公开号：

US09181243B2

申请日:

2014.06.30

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention relates to a crystalline Form M of trametinib dimethyl sulfoxide solvate. Comparing with the prior art, Form M is a more stable crystalline form with better particle size distribution and good flowability and is non-hygroscopic. Therefore, it is more suitable for formulation. The present invention also relates to pharmaceutical compositions thereof, methods of making and using thereof. Trametinib dimethyl sulfoxide solvate has a structure as shown below:

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