THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人:
Erik PROCKO,Jeremiah Dallas HEREDIA
申请号：
US16631275
公开号：
US20200206342A1
申请日:
2018.07.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are HIV-1 Env proteins or fragments thereof comprising one or more amino acid mutations； and nucleic acid molecule encoding the same. Further provided is a method of screening a compound for binding to one or more mutant HIV-1 Env proteins； and methods for eliciting an immune response against an HIV-1 infected cell, comprising administering to a subject an amount of a mutant HIV-1 Env protein, a fragment thereof a mutant HIV-1 Env trimeric complex, or portion thereof, effective to elicit an immune response in the subject. Further provided is a pharmaceutical composition, such as a vaccine, comprising the mutant HIV-1 Env protein or fragment thereof.
