A dissolving and mixing unit for automatically dissolving and mixing medicines includes: a support (2, 102); a dissolving and mixing device (37, 171), which is mounted on the support (2, 102) and includes two piercer bases and at least one dissolving and mixing channel, wherein each dissolving and mixing channel includes two piercers (38, 39) and an elastic infusion hose connecting the two piercers (38, 39), and the two piercers (38, 39) of each dissolving and mixing channel are mounted on the two piercer bases respectively; a peristaltic pump (3, 103, 4, 104), which is mounted on the support (2, 102) and configured to squeeze the elastic infusion hose; first and second bottle-containing modules (7, 14, 49, 108, 109, 120), which are mounted on the support (2, 102) and are configured to hold first and second medicine containers (41, 45, 46, 47, 129, 130, 131, 132, 133, 134, 135, 136) respectively; and a movement mechanism, which is configured to drive at least one of the first bottle-containing module (7, 49, 108, 109) and one piercer base to move so that the piercer (38) on the one piercer base pierces the first medicine container (45, 46, 47, 129, 130, 131, 132, 133, 134, 135, 136) or separates from the first medicine container (45, 46, 47, 129, 130, 131, 132, 133, 134, 135, 136), and configured to drive at least one of the second bottle-containing module (14, 120) and the other piercer base to move so that the piercer (39) on the other piercer base pierces the second medicine container (41) or separates from the second medicine container (41).