10-[(3R)-1-氮雜雙環[2‧2‧2]辛烷-3-基甲基]-10H-吩噻嗪在製備選擇性抑制M1、M2和M3型毒蕈碱受體的藥物中的用途

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专利权人:

PIERRE FABRE MEDICAMENT

发明人:

CLERC, THIERRY,TISNE-VERSAILLES, JACKY,PRZYBYLSKI, CHRISTOPHE

申请号：

HK10100843.7

公开号：

HK1133207B

申请日:

2010.01.27

申请国别(地区):

HK

年份:

2012

代理人:

摘要：

Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine (I) and its salts for the manufacture of a medicament to prevent or treat disorders, diseases and/or pathologies by selectively inhibiting of muscarinic M1 receptor, muscarinic M2 receptor and muscarinic M3 receptor, is claimed. ACTIVITY : Uropathic； Antibacterial； Fungicide. MECHANISM OF ACTION : Muscarinic M1 receptor inhibitor； Muscarinic M2 receptor inhibitor； Muscarinic M3 receptor inhibitor. The effect of (I) to inhibit the muscarinic M1 receptor was tested in Chinese hamster ovary cells using in vitro assay. The results showed that (I) exhibited an IC 5 0 value of 1.6 nM.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/