The present invention relates to a 9-aminomethyl substituted tetracycline compound represented by general formula (I), pharmaceutically acceptable salts, solvates or isomers thereof, wherein R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, Rl0, R11, R12, R13a and R13b are as defined in the specification； the present invention also relates to a method for preparing the compounds； a pharmaceutical composition comprising the compounds； and use of the compounds in the preparation of medicaments for treatment and/or prevention of diseases responsive to tetracyclines.
