The present invention relates to topical pharmaceutical compositions of 2 -Methyl - 41 -trifluoromethoxy-biphenyl -3 - carboxylic acid [6 -(cis - 2, 6 - dimethyl -morpholin - 4 -yl) -pyridin - 3 -yl] - amide, to the use of such compositions in therapeutic applications and to methods for manufacturing such compositions.