Humanized anti-CXCR4 antibody for treating cancer

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专利权人:

ピエール、ファーブル、メディカマン

发明人:

クリスティーヌ、クリンゲル‐アムール,アレクサンドラ、ジュアンオー,ベロニク、グルニエ‐コサネル,スベン、ベルガー

申请号：

JP2013501835

公开号：

JP5749330B2

申请日:

2011.03.30

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention relates to a novel isolated humanized antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. More particularly, the present invention relates to hz515H7 antibodies, specific to the CXCR4 protein, as well as their use for the treatment of cancer. Pharmaceutical compositions composed of such antibodies and a process for the selection of such antibodies are also covered.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/