Compositions, methods, and combination therapies for the treatment of lymphomas, leukemias, melanomas, prostate cancer, and metastatic disease are provided. Specifically, compositions comprising anti-±4 integrin immunoglobulins or immunoglobulins that bind to an ±4 integrin ligand (e.g., MadCAM-1 and VCAM-1) are disclosed for use in inhibiting tumor growth and progression and inhibition of metastases. A preferred immunoglobulin for use in treating tumors and metastases is natalizumab. The compositions and methods using these immunoglobulins can be used alone or in combination with other reagents and cancer treatment modalities.本發明提供治療淋巴瘤、白血病、黑色素瘤、前列腺癌及轉移性疾病之組合物、方法及組合療法。具體而言，本發明揭示包括抗-α4整合素免疫球蛋白或結合於一α4整合素配體(例如，MadCAM-1及VCAM-1)之免疫球蛋白之組合物，其係用於抑制腫瘤生長及進展並抑制轉移。一種用於治療腫瘤及轉移之較佳免疫球蛋白係那他珠單抗(natalizumab)。使用該等免疫球蛋白之組合物及方法可單獨使用或與其他試劑及癌症治療方案結合使用。
