Disclosed in the present invention are an endogenous bacillus megaterium BM18-2 with cadmium enrichment for promoting the growth of hybrid pennisetum and an application thereof. The endogenous bacillus megaterium BM18-2 with cadmium enrichment for promoting the growth of hybrid pennisetum is preserved in China Center for Type Culture Collection in Wuhan University in Wuhan of China on November 10, 2017 with a preservation number of CCTCC NO: M2017679. Further disclosed is a hybrid pennisetum cadmium enrichment growth-promoting microbial inoculum prepared using the bacillus megatherium BM18-2. The BM18-2 according to the present invention can be used for promoting the growth of hybrid pennisetum in cadmium-contaminated soil. By invasion the hybrid pennisetum with the strain, the healthy growth of the hybrid pennisetum in a cadmium-contaminated soil environment can be promoted, thus improving the cadmium content and biomass of the hybrid pennisetum and enhancing remediation efficiency on heavy metal cadmium-contaminated soil.