The purpose of the present invention is to provide an antigen for causing an immune response against various genotypes of HBV. The present invention provides: virus-like particles containing multiple types of HBs-L antigen protein; or a virus-like particle composition obtained by combination thereof.本發明之目的在於提供一種對各種基因型之HBV可誘發免疫反應之抗原,係提供一種類病毒粒子組成物,其係由包含數種類以上之HBs-L抗原蛋白質之類病毒粒子或其等組合而成。