A cyber-physical system (CPS) pressure based sensing system and methods for assessing stance or mobility of a test subject standing or moving are provided. The CPS pressure based sensing system can include at least one piezoresistive transducer configured to obtain a plurality of measurements with respect to the stance or movements of the test subject, and a data analyzer configured to determine patterns of the stance or movement by performing machine learning classification on the plurality of measurements obtained by the at least one piezoresistive transducer.