Provided is a method of increasing the stability of wild-type β- glucocerebrosidase. Alsoprovided are methods of treating and/or preventing an individual having a neurologicaldisease in which increased expression or activity of β-glucocerebrosidase inthe central nervous system would be beneficial. This method comprises administering aneffective amount of a pharmacologic chaperone for β- glucocerebrosidase, withthe proviso that the individual does not have a mutation in the gene encoding β-glucocerebrosidase.Further provided are β-glucocerebrosidase inhibitors which have beenidentified as specific pharmacologic chaperones and which have been shown toincrease activity of β-glucocerebrosidase in vivo in the central nervoussystem.
