Provided herein are methods of treating a disease or disorder associated with dysregulation of histone deacetylase, and more specifically sensitizing and treating chemoresistant cancer comprising administering a therapeutically effective amount of a combination comprising a benzimidazole compound and a DNA hypomethylating agent and kits containing said combination. The preferred DNA hypomethylating agent used in the method is 5-azacitidine azacitidine.
