The present invention involves methods for treatment of breast cancer in a mammal comprising administration to the mammal an effective amount of nanoparticulate curcumin compositions. The methods comprise administering nanoparticulate curcumin compositions through any of the deliverable routes. Parenteral injections of the compositions comprise physiologically acceptable sterile aqueous dispersions. Methods involve administering the provided curcumin compositions in an effective amount in multiple doses, preferably twice a week in the dose range of about 0.5 mg/kg to about 50 mg/kg to said mammal.
